PRIMARY SPINAL CORD GLIOBLASTOMA AN INSTITUTIONAL EXPERIENCE AND REVIEW OF LITERATURE (2024)

Main Article Content

Dr Yogesh Agrawal
Dr Ruchi Agrawal
Dr Ankur Yogi
Dr Anmol Singh Randhawa
Dr Rohin Bhatia
Dr Pankaj Gupta
Dr B S Sharma

Keywords

Primary Spinal Cord Tumor, Spinal Glioblastoma, Intramedullary GBM

Abstract

BACKGROUND: Primary spinal cord glioblastoma multiforme (GBM) is a rare clinical entity and prognosis is very poor. Investigation of choice is MRI and the standard treatment is surgery with maximal safe resection followed by adjuvant radiotherapy and chemotherapy. Several studies show that even after such aggressive treatments, the estimated median survival is around 15 months. Our study reports institutional experience and management of four patients with primary spinal GBM who received treatment in our institute from 2018 to2024. All patients succumbed due to illness.


MATERIAL AND METHOD: We analysed the medical records of all patients retrospectively treated at the Department of the Neurosurgery, Mahatma Gandhi Hospital and Medical College Jaipur INDIA, between May 2018 and December 2023 for primary Spinal intramedullary glioblastoma and we found only 4 patients. Pre-operative data and post-operative results demographic characteristics, were then compared with previous literature regarding spinal GBMs and attempt to identify the related factors.


RESULTS: Subtotal resection was achieved in three patients, while a gross total resection was performed in one case; as per protocol all patients underwent surgery followed by radiotherapy and chemotherapy. No significant intraoperative complications or newer postoperative neurological deficit developed; the median overall survival was 11 months. Progression or recurrence of disease was noted in all patients at the 3-months follow-up despite the adjuvant treatments.


CONCLUSIONS: Till now, there is no fixed protocol regarding specific management of spinal glioblastomas: the extent of resection can play an important role but it appears to be insignificant pertaining to long survival. Time interval between the onset of symptoms and treatment and a smaller extension of the lesion seem to be correlated with better outcomes and increase overall survival. However, there is not an adjunctive viable standardized postoperative therapy yet, which results in concrete and persistent improvement of overall survival and progression free survival.

Abstract 18 | Pdf Downloads 9

References

1.Cohen AR, Wisoff JH, Allen JC, Epstein F. Malignant astrocytomas of the spinal cord. J Neurosurg. 1989;70:50–54.
2.Johnson D, Schwarz S. Intracranial metastases from malignant spinal-cord astrocytoma. Case report. J Neurosurg. 1987;66:621–625.
3.Medhkour A, Chan M. Extremely rare glioblastoma multiforme of the conus medullaris with holocord and brain stem metastases, leading to cranial nerve deficit and respiratory failure: A case report and review of the literature. Surg Neurol. 2005;63:576–582.
4.Ciappetta P, Salvati M, Capoccia G, Artico M, Raco A, Fortuna A. Spinal glioblastoma: report of seven cases and review of the literature. Neurosurgery. 1991;28:302–306.
5.Asano N, Kitamura K, Seo Y, et al. Spinal cord glioblastoma multiforme with intracranial dissemination - case report. Neurol Med Chir (Tokyo) 1990;30:489–494.
6.Grisold W, Pernetzky G, Jellinger K. Giant-cell glioblastoma of the thoracic cord. Acta Neurochir (Wien) 1981;58:121–126.
7.Guidetti B, Mercuri S, Vagnozzi R. Long-term results of the surgical treatment of 129 intramedullary spinal gliomas. J Neurosurg. 1981;54:323–330.
8.B. Behmanesh, M. Setzer, J. Konczalla, P. Harter, J. Quick-Weller, L. Imoehl, K. Franz, F. Gessler, V. Seifert, G. Marquardt. Management of Patients with Primary Intramedullary Spinal Cord Glioblastoma. World Neurosurg., 98 (2017), pp. 198-202
9.S.K. Konar, S.C. Bir, T.K. Maiti, A. Nanda. A systematic review of overall survival in pediatric primary glioblastoma multiforme of the spinal cord. J. Neurosurg. Pediatr., 19 (2) (2017), pp. 239-248
10.F.J. Epstein, J.P. Farmer, D. Freed. Adult intramedullary astrocytomas of the spinal cord. J. Neurosurg., 77 (3) (1992), pp. 355-359
11.W.C. Choi, J.H. Lee, S.H. Lee. Spinal cord glioblastoma multiforme of conus medullaris masquerading as high lumbar disk herniation. Surg. Neurol., 71 (2) (2009), pp. 234-237
12.N. Morais, L. Mascarenhas, J.P. Soares-Fernandes, A. Silva, Z. Magalhães, J.A. Costa. Primary spinal glioblastoma: a case report and review of the literature. Oncol. Lett., 5 (3) (2013), pp. 992-996
13.H. Adams, J. Avendaño, S.M. Raza, Z.L. Gokaslan, G.I. Jallo, A. Quiñones-Hinojosa, Prognostic factors and survival in primary malignant astrocytomas of the spinal cord: a population-based analysis from 1973 to 2007, Spine (Phila Pa 1976) 37 (12) (2012) E727-35.
14.M. Santi, H. Mena, K. Wong, K. Koeller, C. Olsen, E.J. Rushing. Spinal cord malignant astrocytomas. Clinicopathologic features in 36 cases. Cancer, 98 (3) (2003), pp. 554-561
15.R. Stupp, W.P. Mason, M.J. vandenBent, M. Weller, B. Fisher, M.J.B. Taphoorn, K. Belanger, A.A. Brandes, C. Marosi, U. Bogdahn, J. Curschmann, R.C. Janzer, S.K. Ludwin, T. Gorlia, A. Allgeier, D. Lacombe, J.G. Cairncross, E. Eisenhauer, R.O. Mirimanoff Group, Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med., 352 (10) (2005), pp. 987-996
16.Shen CX, Wu JF, Zhao W, Cai ZW, Cai RZ, Chen CM. Primary spinal glioblastoma multiforme: A case report and review of the literature. Med (United States) 2017;96:1–6.
17.Yanamadala V, Koffie RM, Shankar GM, Kumar JI, Buchlak QD, Puthenpura V, et al. Spinal cord glioblastoma: 25 years of experience from a single institution. J Clin Neurosci. 2016;27:138–41.
18.Timmons JJ, Zhang K, Fong J, Lok E, Swanson KD, Gautam S, et al. Literature review of spinal cord glioblastoma. Am J Clin Oncol Cancer Clin Trials. 2018;41:1281–7.
19.Raco A, Piccirilli M, Landi A, Lenzi J, Delfini R, Cantore G. High-grade intramedullary astrocytomas: 30 years’ experience at the neurosurgery department of the university of Rome “sapienza”: Clinical article. J Neurosurg Spine. 2010;12:144–53.
20.McGirt MJ, Goldstein IM, Chaichana KL, Tobias ME, Kothbauer KF, Jallo GI. Extent of surgical resection of malignant astrocytomas of the spinal cord: Outcome analysis of 35 patients. Neurosurgery. 2008;63:55–60.
21.Jokovic M, Somma T, Ilic R, Guizzardi G, Stanimirovic A, Raicevic S, Milicevic M, Grujicic D, Solari D. Primary spinal glioblastoma multiforme. Single center experience and literature review. Interdisciplinary Neurosurgery. 2021 Jun 1;24:101109.
22.S. Lam, Y. Lin, S. Melkonian. Analysis of risk factors and survival in pediatric high-grade spinal cord astrocytoma: a population-based study. Pediatr. Neurosurg., 48 (5) (2012), pp. 299-305
23.H.M. Sandler, S.M. Papadopoulos, A.F. Thornton, D.A. Ross. Spinal cord astrocytomas: results of therapy. Neurosurgery, 30 (4) (1992), pp. 490-493
24.E. Caro-Osorio, J.C. Herrera-Castro, A. Barbosa-Quintana, M. Benvenutti-Regato. Primary Spinal Cord Small-Cell Glioblastoma: Case Report and Literature Review. World Neurosurg., 118 (2018), pp. 69-70
25. X. Cheng, S. Lou, S. Huang, H. Chen, J. Liu. Primary Spinal Cord Glioblastoma Multiforme: A Retrospective Study of Patients at a Single Institution. World Neurosurg., 106 (2017), pp. 113-119
26. A. Liu, E.W. Sankey, C. Bettegowda, P.C. Burger, G.I. Jallo, M.L. Groves Poor prognosis despite aggressive treatment in adults with intramedullary spinal cord glioblastoma. J. Clin. Neurosci., 22 (10) (2015), pp. 1628-1631
27. T. Seki, K. Hida, S. Yano, T. Aoyama, I. Koyanagi, K. Houkin. Surgical Outcomes of High-Grade Spinal Cord Gliomas. Asian Spine J., 9 (6) (2015), pp. 935-941

Article Sidebar

Pdf

Article Details

How to Cite

Dr Yogesh Agrawal, Dr Ruchi Agrawal, Dr Ankur Yogi, Dr Anmol Singh Randhawa, Dr Rohin Bhatia, Dr Pankaj Gupta, & Dr B S Sharma. (2024). PRIMARY SPINAL CORD GLIOBLASTOMA AN INSTITUTIONAL EXPERIENCE AND REVIEW OF LITERATURE. Journal of Population Therapeutics and Clinical Pharmacology, 31(8), 273–281. https://doi.org/10.53555/jptcp.v31i8.7357

  • ACM
  • ACS
  • APA
  • ABNT
  • Chicago
  • Harvard
  • IEEE
  • MLA
  • Turabian
  • Vancouver

Issue

Vol. 31 No. 8 (2024): JPTCP

Section

Articles

PRIMARY SPINAL CORD GLIOBLASTOMA AN INSTITUTIONAL EXPERIENCE AND REVIEW OF LITERATURE (1)

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.

Author Biographies

Dr Yogesh Agrawal

MBBS, MS MCh, Associate Professor, Department of Neurosurgery, Mahatma Gandhi Medical College & Hospital, Jaipur (INDIA),

Dr Ruchi Agrawal

MBBS, MD, Associate Professor, Department of Physiology, Govt. Medical College, Dausa (INDIA), Mob.: 8955260072

Dr Ankur Yogi

MBBS, MD, Assistant Professor, Department of Physiology, Govt. Medical College, Dausa (INDIA)

Dr Anmol Singh Randhawa

Senior Resident, Department of Neurosurgery, Mahatma Gandhi Medical College & Hospital, Jaipur (INDIA),

Dr Rohin Bhatia

MBBS, MS, MCh, Professor, Department of Neurosurgery, Mahatma Gandhi Medical College & Hospital, Jaipur (INDIA).

Dr Pankaj Gupta

MBBS, MS, MCh, Professor & Head, Department of Neurosurgery, Mahatma Gandhi Medical College & Hospital, Jaipur (INDIA),

Dr B S Sharma

MBBS, MS, MCh, Emeritus Professor, Department of Neurosurgery, Mahatma Gandhi Medical College & Hospital, Jaipur (INDIA),

PRIMARY SPINAL CORD GLIOBLASTOMA AN INSTITUTIONAL EXPERIENCE AND REVIEW OF LITERATURE (2024)

References

Top Articles
Axel Tyler Sherd
Bustime B8
Combat level
Wild Smile Stapleton
Aiken County government, school officials promote penny tax in North Augusta
Weapons Storehouse Nyt Crossword
You can put a price tag on the value of a personal finance education: $100,000
414-290-5379
Wildflower1967
About Us | TQL Careers
Maplestar Kemono
Sky X App » downloaden & Vorteile entdecken | Sky X
Imagetrend Inc, 20855 Kensington Blvd, Lakeville, MN 55044, US - MapQuest
Classic | Cyclone RakeAmerica's #1 Lawn and Leaf Vacuum
Honda cb750 cbx z1 Kawasaki kz900 h2 kz 900 Harley Davidson BMW Indian - wanted - by dealer - sale - craigslist
How To Cancel Goodnotes Subscription
Royal Cuts Kentlands
PowerXL Smokeless Grill- Elektrische Grill - Rookloos & geurloos grillplezier - met... | bol
Tyrone Unblocked Games Bitlife
Sodium azide 1% in aqueous solution
8005607994
Riversweeps Admin Login
A Man Called Otto Showtimes Near Cinemark University Mall
Workshops - Canadian Dam Association (CDA-ACB)
Preggophili
Ncal Kaiser Online Pay
Craftsman Yt3000 Oil Capacity
How to Use Craigslist (with Pictures) - wikiHow
+18886727547
Helloid Worthington Login
Www Craigslist Com Shreveport Louisiana
Nsu Occupational Therapy Prerequisites
Lichen - 1.17.0 - Gemsbok! Antler Windchimes! Shoji Screens!
Goodwill Thrift Store & Donation Center Marietta Photos
Panchitos Harlingen Tx
Linabelfiore Of
AsROck Q1900B ITX und Ramverträglichkeit
Dallas City Council Agenda
Winco Money Order Hours
Compare Plans and Pricing - MEGA
Dr Adj Redist Cadv Prin Amex Charge
World Social Protection Report 2024-26: Universal social protection for climate action and a just transition
Lake Andes Buy Sell Trade
Oklahoma City Farm & Garden Craigslist
Frequently Asked Questions
Race Deepwoken
What your eye doctor knows about your health
Tyrone Unblocked Games Bitlife
Houston Primary Care Byron Ga
Charlotte North Carolina Craigslist Pets
Craigslist.raleigh
Cataz.net Android Movies Apk
Latest Posts
Article information

Author: Catherine Tremblay

Last Updated:

Views: 6156

Rating: 4.7 / 5 (47 voted)

Reviews: 86% of readers found this page helpful

Author information

Name: Catherine Tremblay

Birthday: 1999-09-23

Address: Suite 461 73643 Sherril Loaf, Dickinsonland, AZ 47941-2379

Phone: +2678139151039

Job: International Administration Supervisor

Hobby: Dowsing, Snowboarding, Rowing, Beekeeping, Calligraphy, Shooting, Air sports

Introduction: My name is Catherine Tremblay, I am a precious, perfect, tasty, enthusiastic, inexpensive, vast, kind person who loves writing and wants to share my knowledge and understanding with you.